Inhibitory effect of super-hydrophobicity on silver release and antibacterial properties of super-hydrophobic Ag/TiO2 nanotubes

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• 作者：Licheng Zhang ; Lihai Zhang ; Yun Yang ; Wei Zhang ; Houchen Lv ; Fei Yang ; Changjian Lin and Peifu Tang
• 刊名：Journal of Biomedical Materials Research Part B: Applied Biomaterials
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：104
• 期：5
• 页码：1004-1012
• 全文大小：852K
• ISSN：1552-4981

文摘

The antibacterial properties of super-hydrophobic silver (Ag) on implant surface have not yet to be fully illuminated. In our study, we investigate the protective effects of super-hydrophobic coating of silver/titanium dioxide (Ag/TiO₂) nanotubes against bacterial pathogens, as well as its pattern of Ag release. Ag/TiO₂ nanotubes are prepared by a combination of electrochemical anodization and pulse electrodeposition. The super-hydrophobic coating is prepared by modifying the surface of Ag/TiO₂ nanotubes with 1H, 1H, 2H, 2H-perfluorooctyl-triethoxysilane (PTES). Surface features and Ag release are examined by SEM, X-ray photoelectron spectroscopy, contact-angle measurement, and inductively coupled plasma-mass spectrometry (ICP-MS). The antibacterial activity of super-hydrophobic coating Ag/TiO₂ nanotubes is investigated both in vitro and in vivo. Consequently, the super-hydrophobic coating on Ag/TiO₂ nanotubes shows a regularly arranged structure; and nano-Ag particles (10–30 nm) are evenly distributed on the surface or inside the nanotubes. The contact angles of water on the super-hydrophobic coating Ag/TiO₂ nanotubes are all above 150°. In addition, the super-hydrophobic character displays a certain conserved effect that contributes to the sustained release of Ag. The super-hydrophobic Ag/TiO₂ nanotubes are also effective in inhibiting bacterial adhesion, killing the adhering bacteria and preventing postoperative infection in rabbits. Therefore, it is expected that the super-hydrophobic Ag/TiO₂ nanotubes which can contain the release of Ag, leading to stable release, may show a consistent surface antibacterial capability.