Baeckeins J and K, Two Novel C-Methylated Biflavonoids from the Roots of Baeckea frutescens and Their Cytoprotective Activities

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• 作者：Bei-Xi Jia ; Ao Jia ; Chao-Jie Li ; Hui-Qin Zhao ; Feng-Xiao Ren ; Hong-Min Liu and Qiang Wang
• 刊名：Helvetica Chimica Acta
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：99
• 期：7
• 页码：499-505
• 全文大小：705K
• ISSN：1522-2675

文摘

Baeckea frutescens is an aromatic shrub used as ornamentals and as food flavor spices in the southern part of P. R. China. Two novel C-methylated biflavonoids named baeckeins J (1) and K (2) were isolated from the roots of B. frutescens, which possessed the unique carbon skeleton conjugated of a flavonol and one isoflavanonol molecule via the linkages of C(2)–C(8*) and C(3)–O–C(7*). The structures of compounds 1 and 2 were elucidated by analysis of 1D- and 2D-NMR, and HR-ESI-MS spectral data, and the absolute configuration for chiral C-atoms C(2) and C(3) were assigned by CD spectrometry combined with quantum chemical calculations. In the bioassay, baeckeins J and K exhibited strong cytoprotective effects on H₂O₂-induced oxidative cell death in PC12 cells.