Piptadenin, a Novel 3,4-Secooleanane Triterpene and Piptadenamide, a New Ceramide from the Stem Bark of Piptadeniastrum africanum (<span class="smallCaps">Hookspan>.f.) <span class="smallCaps">Brenanspan>
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- 作者：Amadou Dawé ; Marius Mbiantcha ; Yannick Fongang ; William Yosseu Nana ; Fawai Yakai ; Gilbert Ateufack ; Muhammad Ali Shaiq ; Iqbal Lubna ; Mehreen Lateef and Bonaventure Tchaleu Ngadjui
- 刊名：Chemistry & Biodiversity
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：14
- 期：2
- 全文大小：232K
- ISSN：1612-1880
文摘
Piptadenin (1), a new triterpene along with piptadenamide (10), a new ceramide, have been isolated from the AcOEt-soluble fraction of the MeOH extract of the stem bark of Piptadeniastrum africanum along with nine known compounds, 1-O-[(3β,22β)-3,22-dihydroxy-28-oxoolean-12-en-28-yl]-β-<span class="smallCaps">dspan>-glucopyranose (2), 22β-hydroxyoleanic acid (3), oleanic acid (4), lupeol (5), betulinic acid (6), 5α-stigmasta-7,22-dien-3β-ol (7), 5α-stigmasta-7,22-dien-3-one (8), (3β)-stigmast-5-en-3-yl β-<span class="smallCaps">dspan>-glucopyranoside (9) and 2,3-dihydroxypropyl hexacosanoate (11). Except for compound 11, all the isolated compounds are reported for the first time from this plant. The structures of the isolated compounds were elucidated by spectroscopic data including 1D and 2D NMR. The pure compounds 1 – 11 were subjected to the pharmacological screening and compounds 2, 5 – 7 and 9 exhibited potent urease inhibitory activity with IC<sub>50sub> value of 25.8, 28.9, 30.1, 31.8 and 32.7 μ<span class="smallCaps">mspan>, respectively, whereas compound 1 showed moderate activity (IC<sub>50sub> = 98.7 μ<span class="smallCaps">mspan>). The potent urease inhibitory activity supplemented the previous literature reports and medicinal uses of this plant.