Prevalence and Factors Associated with Subclinical Left Ventricular Systolic Dysfunction Evaluated by Mid-Wall Mechanics in Rheumatoid Arthritis

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• 作者：Giovanni Cioffi ; Ombretta Viapiana ; Federica Ognibeni ; Elena Fracassi ; Alessandro Giollo ; Silvano Adami ; Davide Gatti ; Carmine Mazzone ; Giorgio Faganello ; Andrea Di Lenarda and Maurizio Rossini
• 刊名：Echocardiography
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：33
• 期：9
• 页码：1290-1299
• 全文大小：317K
• ISSN：1540-8175

文摘

Patients with rheumatoid arthritis (RA) have an increased cardiovascular event rate, mainly due to the arterial stiffness which leads to coronary atherosclerosis and concentric left ventricular (LV) geometry. These conditions predispose to LV systolic dysfunction (LVSD), which can be detected by stress-corrected mid-wall shortening (sc-MS), an early prognosticator of cardiovascular events in asymptomatic patients with arterial hypertension and/or diabetes. In these subjects, sc-MS is frequently impaired even though LV ejection fraction (LVEF) is preserved. In this study, we analyzed the prevalence and the factors associated with asymptomatic LVSD measured by sc-MS among patients with RA and verified whether RA per se was independently related to LVSD.