Effects of glucagon-like peptide-1 on the differentiation and metabolism of human adipocytes
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- 作者：Rajaa El Bekay ; Leticia Coí ; n-Aragü ; ez ; Diego Ferná ; ndez-Garcí ; a ; Wilfredo Oliva-Olivera ; Rosa Bernal-Ló ; pez ; Mercedes Clemente-Postigo ; Javier Delgado-Lista ; Alberto Diaz-Ruiz ; Rocí ; o Guzman-Ruiz ; Rafael Vá ; zquez-Martí ; nez ; Said Lhamyani ; Marí ; a Mar Roca-Rodrí ; guez ; Sonia Fernandez Veledo ; Joan Vendrell ; Marí ; a M. Malagó ; n and Francisco José ; Tinahones
- 刊名：British Journal of Pharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：173
- 期：11
- 页码：1820-1834
- 全文大小：2117K
- ISSN：1476-5381
文摘
Glucagon-like peptide-1 (GLP-1) analogues improve glycaemic control in type 2 diabetic (T2D) patients and cause weight loss in obese subjects by as yet unknown mechanisms. We recently demonstrated that the GLP-1 receptor, which is present in adipocytes and the stromal vascular fraction of human adipose tissue (AT), is up-regulated in AT of insulin-resistant morbidly obese subjects compared with healthy lean subjects. The aim of this study was to explore the effects of in vitro and in vivo administration of GLP-1 and its analogues on AT and adipocyte functions from T2D morbidly obese subjects.