The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury
详细信息 查看全文
- 作者：Janette Nallely Corona-Ramos ; Minarda De la O-Arciniega ; Myrna Dé ; ciga-Campos ; José ; Raú ; l Medina-Ló ; pez ; Adriana Miriam Domí ; nguez-Ramí ; rez ; Osmar Antonio Jaramillo-Morales ; Josué ; Vidal Espinosa-Juá ; rez and Francisco Javier Ló ; pez-Muñ ; oz
- 刊名：Drug Development Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：77
- 期：5
- 页码：217-226
- 全文大小：343K
- ISSN：1098-2299
文摘
The current work evaluates the interaction between two commonly used drugs, tramadol (Tra) and gabapentin (Gbp). Dose-response curves (DRC) and isobolographic analysis were used to confirm their synergistic antihyperalgesic and anti-allodynic responses in a rat neuropathic pain model involving chronic constriction injury of the sciatic nerve and in von Frey and acetone tests. Tra and Gbp produced dose-dependent antihyperalgesic and anti-allodynic effects. Dose-response studies of combinations of Tra and Gbp in combination showed the DRC was leftward-shifted compared to the DRCs for each compound alone. One combination demonstrated both antihyperalgesic and anti-allodynic effects greater than those observed after individual administration. The remaining combinations demonstrated an additive effect. The Tra+Gbp combination demonstrated a potentiative effect with smaller doses of Tra. Additionally, it was determined lethal dose 50 (LD50) of Tra alone and tramadol + Gbp 10 using mice to 48 h post administration. The DRC (death) were similar for Tra alone and in Tra in combination, despite the improved effectiveness of Tra in the presence of GBP, 10 mg/kg. A combination of these drugs could be effective in neuropathic pain therapy because they can produce potentiative (at a low dose) or additive effects. Drug Dev Res 77 : 217–226, 2016.