Antinociceptive Interactions Between Meloxicam and Gabapentin in Neuropathic Pain Depend on the Ratio used in Combination in Rats
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- 作者：Josué ; Vidal Espinosa-Juá ; rez ; Osmar Antonio Jaramillo-Morales ; Janette Nallely Corona-Ramos ; José ; Raú ; l Medina-Ló ; pez and Francisco Javier Ló ; pez-Muñ ; oz
- 关键词：neuropathic pain ; meloxicam ; gabapentin ; interaction ; additive effect
- 刊名：Drug Development Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：77
- 期：3
- 页码：134-142
- 全文大小：471K
- ISSN：1098-2299
文摘
Neuropathic pain is particularly difficult to treat because of its diverse etiologies and underlying pathophysiological mechanisms. Drug combinations have been proposed to effectively treat some neuropathies. In the present study the interaction of five combinations of meloxicam and gabapentin, were studied to assess the possible synergistic antinociceptive response in neuropathic pain using the von Frey and acetone tests in rat models. Coadministration of meloxicam and gabapentin increased the antihyperalgesic or antiallodynic effects as compared with the compounds administered alone. The area under the curve (AUC) of the antihyperalgesic effects produced by the combination of the two drugs was generally similar to the theoretical sum of effects produced by each drug alone. However, the AUC of the antiallodynic effect produced by one combination (meloxicam 1.0 mg/kg + gabapentin 10 mg/kg) was greater than the theoretical sum of the effects produced by each drug alone. The type of final interaction on the drug combinations can be additive or cause potentiation of antinociceptive effects and depends on the proportion of each compound used in dosing. Drug Dev Res 77 : 134–142, 2016.