Effortful control as a dimension of temperament is negatively associated with prefrontal serotonin transporter availability in obese and non-obese individuals
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- 作者：Franziska Zientek ; Karsten Winter ; Astrid Mü ; ller ; Michael Rullmann ; Julia Luthardt ; Georg-Alexander Becker ; Anke Bresch ; Marianne Patt ; Osama Sabri ; Anja Hilbert and Swen Hesse
- 刊名：European Journal of Neuroscience
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：7
- 页码：2460-2466
- 全文大小：312K
- ISSN：1460-9568
文摘
There is evidence that temperamental factors are associated with obesity; however, the biological mechanism of such association remains elusive. We aimed to investigate a possible association between serotonin transmission and regulative temperament in obese and non-obese individuals by using positron emission tomography (PET) imaging of serotonin transporters (SERT) and the Adult Temperament Questionnaire. Twenty-nine obese individuals with body mass index (BMI) ≥ 35 kg/m2 and 13 non-obese controls (BMI < 30 kg/m2) underwent PET with [11C]-labeled DASB (highly selective for SERT) and self-completed the Effortful Control (EC) scale of the Adult Temperament Questionnaire-Short Form (ATQ). With the help of this questionnaire, we aimed to assess the capacity of self-regulation. Overall, for obese and non-obese individuals together, VOI-based (volume of interest) analysis showed significant negative correlations between SERT BPND and ATQ-EC AC (Activation Control) subscale in several brain regions (all r ≤ −0.47). Obese and non-obese individuals separated showed equally strong positive, but non-significant correlations. The analysis did not reveal any significant correlations of SERT availability and ATQ-EC IC (Inhibitory Control) or ATQ-EC AtC (Attentional Control) subscale within and between the two groups. The results indicate that regulative temperament – particularly the capacity to mitigate negatively toned impulses and to resist inappropriate avoidance behavior – might be associated with the prefrontal serotonergic system.