Focal adhesion kinase: predictor of tumour response and risk factor for recurrence after neoadjuvant chemoradiation in rectal cancer

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• 作者：Teresa Gó ; mez del Pulgar ; Arancha Cebriá ; n ; Maria Jesú ; s Ferná ; ndez-Aceñ ; ero ; Aurea Borrero-Palacios ; Laura del Puerto-Nevado ; Javier Mart&#237 ; nez-Useros ; Juan Pablo Mar&#237 ; n-Arango ; Cristina Caramé ; s ; Ricardo Vega-Bravo ; Mar&#237 ; a Rodr&#237 ; guez-Rem&#237 ; rez ; Marlid Cruz-Ramos ; Fé ; lix Manzarbeitia and Jesú ; s Garc&#237 ; a-Foncillas
• 刊名：Journal of Cellular and Molecular Medicine
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：20
• 期：9
• 页码：1729-1736
• 全文大小：316K
• ISSN：1582-4934

文摘

Rectal cancer represents about 30% of colorectal cancers, being around 50% locally advanced at presentation. Chemoradiation (CRT) followed by total mesorectal excision is the standard of care for these locally advanced stages. However, it is not free of adverse effects and toxicity and the complete pathologic response rate is between 10% and 30%. This makes it extremely important to define factors that can predict response to this therapy. Focal adhesion kinase (FAK) expression has been correlated with worse prognosis in several tumours and its possible involvement in cancer radio- and chemosensitivity has been suggested; however, its role in rectal cancer has not been analysed yet. To analyse the association of FAK expression with tumour response to CRT in locally advanced rectal cancer. This study includes 73 patients with locally advanced rectal cancer receiving standard neoadjuvant CRT followed by total mesorectal excision. Focal adhesion kinase protein levels were immunohistochemically analysed in the pre-treatment biopsies of these patients and correlated with tumour response to CRT and patients survival. Low FAK expression was significantly correlated with local and distant recurrence (P = 0.013). Low FAK expression was found to be a predictive marker of tumour response to neoadjuvant therapy (P = 0.007) and patients whose tumours did not express FAK showed a strong association with lower disease-free survival (P = 0.01). Focal adhesion kinase expression predicts neoadjuvant CRT response in rectal cancer patients and it is a clinically relevant risk factor for local and distant recurrence.