The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro
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- 作者：Attilio Pingitore ; Edward S. Chambers ; Thomas Hill ; Inmaculada Ruz Maldonado ; Bo Liu ; Gavin Bewick ; Douglas J. Morrison ; Tom Preston ; Gareth A. Wallis ; Catriona Tedford ; Ramó ; n Castañ ; era Gonzá ; lez ; Guo C. Huang ; Pratik Choudhary ; Gary Frost and Shanta J. Persaud
- 刊名：Diabetes, Obesity and Metabolism
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：19
- 期：2
- 页码：257-265
- 全文大小：1292K
- ISSN：1463-1326
文摘
Diet-derived short chain fatty acids (SCFAs) improve glucose homeostasis in vivo, but the role of individual SCFAs and their mechanisms of action have not been defined. This study evaluated the effects of increasing colonic delivery of the SCFA propionate on β-cell function in humans and the direct effects of propionate on isolated human islets in vitro.