N-Heterocyclic carbenes derived from imidazo-[1,5-a]pyridines related to natural products: synthesis, structure and potential biological activity of some corresponding gold(I) and silver(I) complexes

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• 作者：Monica Mihorianu ; M Heiko Franz ; Peter G Jones ; Matthias Freytag ; Gerhard Kelter ; Heinz-Herbert Fiebig ; Matthias Tamm and Ion Neda
• 刊名：Applied Organometallic Chemistry
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：30
• 期：7
• 页码：581-589
• 全文大小：1343K
• ISSN：1099-0739

文摘

A series of Au(I) complexes () and Ag(I) complexes () derived from imidazo[1,5-a]pyridin-3-ylidenes were synthesized from AuCl(SMe₂) or by reacting silver(I) acetate with 2,5-dimethylimidazo[1,5-a]pyridin-2-ium iodide or imidazo[1,5-a]pyridin-2-ium salts, and were characterized using NMR spectroscopy, mass spectrometry and elemental analyses. In addition, the Au(I) complex and the Ag(I) complex were characterized using single-crystal X-ray diffraction. Using paclitaxel as a standard, all Au(I) and Ag(I) N-heterocyclic carbene complexes were evaluated for their in vitro anti-tumour activity against 12 cell lines using a monolayer cell survival and proliferation assay. The highest anticancer activity was found for complexes , and with mean IC₅₀ values of 10.09, 10.42 and 12.28 μM, respectively. Copyright