The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell-driven inflammatory responses
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- 作者：Virginia Delgado-Maroto ; Clara P Falo ; Irene Forte-Lago ; Norma Adan ; Maria Morell ; Elena Maganto-Garcia ; Gema Robledo ; Francisco O'Valle ; Andrew H Lichtman ; Elena Gonzalez-Rey and Mario Delgado
- 刊名：British Journal of Pharmacology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：174
- 期：3
- 页码：267-280
- 全文大小：1444K
- ISSN：1476-5381
文摘
Myocarditis is an inflammatory and autoimmune cardiovascular disease that causes dilated myocardiopathy and is responsible for high morbidity and mortality worldwide. Cortistatin is a neuropeptide produced by neurons and cells of the immune and vascular systems. Besides its action in locomotor activity and sleep, cortistatin inhibits inflammation in different experimental models of autoimmune diseases. However, its role in inflammatory cardiovascular disorders is unexplored. Here, we investigated the therapeutic effects of cortistatin in a well-established preclinical model of experimental autoimmune myocarditis (EAM).