Reduced alloimmunization in mice following repeated transfusion with pathogen-reduced platelets

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• 作者：Marcus O. Muench ; John W. Heitman ; Heather Inglis ; Marina E. Fomin ; Susanne Marschner ; Raymond P. Goodrich ; Philip J. Norris and Rachael P. Jackman
• 刊名：Transfusion
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：56
• 期：6
• 页码：1419-1429
• 全文大小：677K
• ISSN：1537-2995

文摘

Allogeneic transfusion can result in alloimmunization, leading to platelet (PLT) refractoriness and rejection of solid organ transplants. Previously we demonstrated that pathogen reduction using UV light and riboflavin (UV + R) eliminates the immunogenicity of white blood cells (WBCs) in vitro, blocks alloimmunization from transfusion in mice, and results in reduced ex vivo cytokine responses to subsequent untreated transfusions. We sought to determine if repeated transfusion with pathogen-reduced PLT-rich plasma (PRP) would eventually cause breakthrough alloimmunization or enhanced tolerance.