Combined high-fat-resveratrol diet and RIP140 knockout mice reveal a novel relationship between elevated bone mitochondrial content and compromised bone microarchitecture, bone mineral mass, and bone strength in the tibia
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- 作者：Paula M. Miotto ; Scott Frendo-Cumbo ; Sandra M. Sacco ; David C. Wright ; Wendy E. Ward and Graham P. Holloway
- 刊名：Molecular Nutrition & Food Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：60
- 期：9
- 页码：1994-2007
- 全文大小：599K
- ISSN：1613-4133
文摘
While resveratrol (RSV) is associated with the prevention of high-fat (HF) diet-induced insulin resistance, the effects on bone health combined with an HF-diet is unknown. Therefore, we determined the effect of RSV on bone microarchitecture in the presence of an HF-diet, while also elucidating molecular adaptations within bone that could contribute to bone health status.