F16357, a novel protease-activated receptor 1 antagonist, improves urodynamic parameters in a rat model of interstitial cystitis

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• 作者：N Monjotin ; J Gillespie ; M Farrié ; B Le Grand ; D Junquero and N Vergnolle
• 刊名：British Journal of Pharmacology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：173
• 期：14
• 页码：2224-2236
• 全文大小：1427K
• ISSN：1476-5381

文摘

The aims of the present study were to characterize the role of PAR1 in rat bladder under inflammatory conditions and determine whether a selective PAR1 antagonist, F16357, can prevent the pathophysiological symptoms of cyclophosphamide-induced interstitial cystitis (IC).