A Hyperpolarizable ¹H Magnetic Resonance Probe for Signal Detection 15 Minutes after Spin Polarization Storage

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• 作者：Dr. Soumya S. Roy ; Dr. Philip Norcott ; Dr. Peter J. Rayner ; Prof. Dr. Gary G. R. Green and Prof. Dr. Simon B. Duckett
• 刊名：Angewandte Chemie International Edition
• 出版年：2016
• 出版时间：December 12, 2016
• 年：2016
• 卷：55
• 期：50
• 页码：15642-15645
• 全文大小：1035K
• ISSN：1521-3773

文摘

Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are two extremely important techniques with applications ranging from molecular structure determination to human imaging. However, in many cases the applicability of NMR and MRI are limited by inherently poor sensitivity and insufficient nuclear spin lifetime. Here we demonstrate a cost-efficient and fast technique that tackles both issues simultaneously. We use the signal amplification by reversible exchange (SABRE) technique to hyperpolarize the target ¹H nuclei and store this polarization in long-lived singlet (LLS) form after suitable radiofrequency (rf) pulses. Compared to the normal scenario, we achieve three orders of signal enhancement and one order of lifetime extension, leading to ¹H NMR signal detection 15 minutes after the creation of the detected states. The creation of such hyperpolarized long-lived polarization reflects an important step forward in the pipeline to see such agents used as clinical probes of disease.