Catalyst-Free Difunctionalization of Activated Alkenes in Water: Efficient Synthesis of β-Keto Sulfides and Sulfones
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- 作者：Huamin Wang ; Guangyu Wang ; Dr. Qingquan Lu ; Chien-Wei Chiang ; Pan Peng ; Jiufu Zhou and Prof. Aiwen Lei
- 刊名：Chemistry - A European Journal
- 出版年：2016
- 出版时间：October 4, 2016
- 年：2016
- 卷：22
- 期：41
- 页码：14489-14493
- 全文大小：589K
- ISSN：1521-3765
文摘
Difunctionalization of activated alkenes, a powerful strategy in chemical synthesis, has been accomplished for direct synthesis of a series of β-keto sulfides and β-keto sulfones. The transformation, mediated by O2, proceeds smoothly in water and without any catalyst. Prominent advantages of this method include mild reaction conditions, purification simplicity, and gram-scale synthesis, underlining the practical utility of this methodology.