Chemoresistant lung cancer stem cells display high DNA repair capability to remove cisplatin-induced DNA damage
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- 作者：Wai-Kin Yu ; Zhigang Wang ; Chi-Chun Fong ; Dandan Liu ; Tak-Chun Yip ; Siu-Kie Au ; Guangyu Zhu and Mengsu Yang
- 刊名：British Journal of Pharmacology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：174
- 期：4
- 页码：302-313
- 全文大小：1165K
- ISSN：1476-5381
文摘
The persistence of lung cancer stem cells (LCSCs) has been proposed to be the main factor responsible for the recurrence of lung cancer as they are highly resistant to conventional chemotherapy. However, the underlying mechanisms are still unclear.