Application of HIF-1 by gene therapy enhances angiogenesis and osteogenesis in alveolar bone defect regeneration

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• 作者：Yang Zhang ; Jiao Huang ; Chao Wang ; Yan Zhang ; Changhong Hu ; Guangyue Li and Ling Xu
• 刊名：The Journal of Gene Medicine
• 出版年：2016
• 出版时间：April-June 2016
• 年：2016
• 卷：18
• 期：4-6
• 页码：57-64
• 全文大小：2871K
• ISSN：1521-2254

文摘

A successful clinical outcome for implanted tissue-engineered bone is dependent on the establishment of a functional vascular network. Gene-enhanced tissue engineering represents a promising approach for vascularization and osteogenesis. In the present study, we tested the angiogenesis and osteogenesis efficacy of gelatin as the scaffold carrier in combination with a virus encoding the HIF-1α gene in a rat alveolar bone defect model.