New Chiral Reagent for Installation of Pharmacophoric (S)- or (R)-2-(Alkoxyphosphono)-1-amino-2,2-difluoroethyl Groups
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- 作者：Chen Xie ; Lijun Zhang ; Dr. Haibo Mei ; Dr. Romana Pajkert ; Dr. Maksym Ponomarenko ; Dr. Yi Pan ; Prof. Dr. Gerd-Volker Rö ; schenthaler ; Prof. Dr. Vadim A. Soloshonok and Dr. Jianlin Han
- 刊名：Chemistry - A European Journal
- 出版年：2016
- 出版时间：May 17, 2016
- 年：2016
- 卷：22
- 期：21
- 页码：7036-7040
- 全文大小：574K
- ISSN：1521-3765
文摘
A new chiral reagent has been developed for generalized installation of pharmacophoric (S)- or (R)-2-(alkoxyphosphono)-1-amino-2,2-difluoroethyl group into organic compounds. The original synthetic application of this new reagent is exemplified by Friedel–Crafts reactions with indoles, which proceed efficiently with excellent diastereoselectivity to give enantiomerically pure products.