Inside Cover: New Chiral Reagent for Installation of Pharmacophoric (S)- or (R)-2-(Alkoxyphosphono)-1-amino-2,2-difluoroethyl Groups (Chem. Eur. J. 21/2016)
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- 作者：Chen Xie ; Lijun Zhang ; Dr. Haibo Mei ; Dr. Romana Pajkert ; Dr. Maksym Ponomarenko ; Dr. Yi Pan ; Prof. Dr. Gerd-Volker Rö ; schenthaler ; Prof. Dr. Vadim A. Soloshonok and Dr. Jianlin Han
- 刊名：Chemistry - A European Journal
- 出版年：2016
- 出版时间：May 17, 2016
- 年：2016
- 卷：22
- 期：21
- 页码：6990
- 全文大小：2212K
- ISSN：1521-3765
文摘
Asymmetric methods for practical synthesis of fluorine-containing compounds are in extremely high demand in virtually all branches of the chemical industry. This work introduces a new chiral reagent for generalized installation of pharmacophoric (S)- or (R)-2-(alkoxyphosphono)-1-amino-2,2 difluoroethyl group into organic compounds. The original synthetic application of this new reagent is exemplified by Friedel–Crafts reactions with various indole derivatives, which proceed with excellent stereochemical outcome. More information can be found in the Communication by G.-V. Röschenthaler, V. A. Soloshonok, J. Han et al. on page 7036 ff.