Design and Synthesis of 2-Methyl-7-aminobenzoxazole as Auxiliary in the Palladium(II)-Catalyzed Arylation of a beta-Positioned C(sp3)H Bond
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- 作者：Feihua Luo ; Jun Yang ; Zhengkai Li ; Haifeng Xiang and Xiangge Zhou
- 关键词：arylation ; benzoxazoles ; catalysis ; CH activation ; directing group
- 刊名：Advanced Synthesis & Catalysis
- 出版年：2016
- 出版时间：March 17, 2016
- 年：2016
- 卷：358
- 期：6
- 页码：887-893
- 全文大小：482K
- ISSN：1615-4169
文摘
A palladium(II)-catalyzed direct arylation of methylene C(sp3)H bonds by 2-methyl-7-aminobenzoxazole as an effective auxiliary is reported. This process exhibited high beta-site selectivity, broad substrate scope, and compatibility with different functional groups with moderate to high yields up to 89%.