ChemInform Abstract: A Strecker Approach to 2-Substituted Ethyl 5-Aminothiazole-4-carboxylates.

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• 作者：Ken Cheng ; Andrew McClory ; Whitney Walker ; Jie Xu ; Haiming Zhang ; Remy Angelaud and Francis Gosselin
• 刊名：ChemInform
• 出版年：2016
• 出版时间：July, 2016
• 年：2016
• 卷：47
• 期：32
• 全文大小：22K
• ISSN：1522-2667

文摘

The three step sequence for the synthesis of the title thiazoles involves the 1,2-addition of thioamides to glyoxylate (II), the treatment with acetyl chloride, and finally the Strecker addition-cyclization reaction of the resulting imine precursors.