The role of N-glycosylation in high glucose-induced upregulation of intercellular adhesion molecule-1 on bovine retinal endothelial cells

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• 作者：Kun Liu ; Haiyun Liu ; Zhihua Zhang ; Wen Ye and Xun Xu
• 刊名：Acta Ophthalmologica
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：94
• 期：4
• 页码：353-357
• 全文大小：254K
• ISSN：1755-3768

文摘

The development of diabetic retinopathy has been implicated as a consequence of chronic inflammation. Given the role of the intercellular adhesion molecule-1 (ICAM-1) in inflammation, the potential effect of N-glycosylation on the upregulated expression of ICAM-1 at the surface of bovine retinal endothelial cells (BRECs) induced by high glucose concentrations was investigated.