Characterization of circular RNAs landscape in multiple system atrophy brain
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- 作者：Bei Jun Chen ; James D. Mills ; Konii Takenaka ; Nicola Bliim ; Glenda M. Halliday and Michael Janitz
- 刊名：Journal of Neurochemistry
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：139
- 期：3
- 页码：485-496
- 全文大小：791K
- ISSN：1471-4159
文摘
Circular RNAs (circRNAs) have been recently identified as a naturally occurring family of widespread and diverse endogenous non-coding RNAs that may regulate gene expression in mammals. They are unusually stable RNA molecules with cell type- or developmental stage-specific expression patterns. However, the role of circRNAs in pathology of complex disease is entirely unknown. Here, we report the specific circular transcriptome in the multiple system atrophy (MSA) brain as determined by RNA sequencing. Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP1, were identified and validated as specifically over-expressed in MSA frontal cortex. The expression levels of linear transcripts were not significantly altered and thus did not follow the pattern of their circular counterparts. Further analysis of expression of five MSA-specific circRNAs revealed their over-expression in the white matter of the MSA cortical tissue. Together, this is the first report describing perturbation of circular transcriptome in α-synucleinopathies.