Synthesis and In Vitro Antitumor Activity of New Isoxazolo[5,4-d]Pyrimidine Systems

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• 作者：Wafaa S. Hamama ; Mona E. Ibrahim and Hanafi H. Zoorob
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：53
• 期：6
• 页码：2007-2012
• 全文大小：440K
• ISSN：1943-5193

文摘

The reaction of 5-amino-3-methylisoxazole () with aldimines gave basic side chain 5-amino-3-methylisoxazole derivatives . Annulations of derivatives with anisaldehyde afforded the target isoxazolo[5,4-d]pyrimidines . Treatment of with isatin ketimine anil resulted in the formation of derivative , which further cyclized with anisaldehyde afforded the spirotetracyclic system . Mannich reaction of with primary amine such as methylamine and benzylamine gave the corresponding isoxazolo[5,4-d]pyrimidine derivatives and , respectively. The newly synthesized compounds were tested for their antitumor activity.