文摘
A visible-light-mediated [3+3] annulation of tertiary amines with α-trifluoromethyl alkenes was developed. The reaction offers a direct route to fluorinated tetrahydropyridines and azabicyclo[3.m.1] frameworks under very mild conditions. This protocol presents a rare example of dual sp<sup>3sup> C−H functionalization of tertiary amines with the formation of two different C−C bonds (one sp<sup>3sup>–sp<sup>3sup> bond, one sp<sup>2sup>–sp<sup>3sup> bond). Moreover, two consecutive C−F substitutions in a trifluoromethyl group were achieved in one pot using visible light photoredox catalysis, which enables an unprecedented ring construction.