Back Cover: Chemoselective, Substrate-directed Fluorination of Functionalized Cyclopentane β-Amino Acids (Chem. Asian J. 23/2016)
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- 作者：Dr. Lorá ; nd Kiss ; Dr. Melinda Nonn ; Prof. Reijo Sillanpä ; ä ; Prof. Matti Haukka ; Prof. Santos Fustero and Prof. Ferenc Fü ; lö ; p
- 刊名：Chemistry – An Asian Journal
- 出版年：2016
- 出版时间：December 6, 2016
- 年：2016
- 卷：11
- 期：23
- 页码：3465
- 全文大小：2380K
- ISSN：1861-471X
文摘
Although fluorinated organic compounds are virtually nonexistent in nature, around 25 % of the drugs on the market contain one or more fluorine atoms, the proportion of fluorinated derivatives among agrochemicals (antifungal agents, insecticides and herbicides) being even higher. This work describes a substrate-directed method for fluorination of some highly functionalized cyclopentane derivatives. The cyclic products incorporating CH2F or CHF2 moieties in their structure have been synthesized from diexo- or diendo-norbornene β-amino acids following a stereocontrolled strategy. More information can be found in the Full Paper by F. Fülöp et al. on page 3376 in Issue 23, 2016 (DOI: 10.1002/asia.201601046). In the cover image, the Velvet foot mushroom (Flammulina velutipes, also known as enoki, enokitake, golden needle) is shown.