Chemoselective, Substrate-directed Fluorination of Functionalized Cyclopentane β-Amino Acids
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- 作者：Dr. Lorá ; nd Kiss ; Dr. Melinda Nonn ; Prof. Reijo Sillanpä ; ä ; Prof. Matti Haukka ; Prof. Santos Fustero and Prof. Ferenc Fü ; lö ; p
- 刊名：Chemistry – An Asian Journal
- 出版年：2016
- 出版时间：December 6, 2016
- 年：2016
- 卷：11
- 期：23
- 页码：3376-3381
- 全文大小：1102K
- ISSN：1861-471X
文摘
This work describes a substrate-directed fluorination of some highly functionalized cyclopentane derivatives. The cyclic products incorporating CH2F or CHF2 moieties in their structure have been synthesized from diexo- or diendo-norbornene β-amino acids following a stereocontrolled strategy. The synthetic study was based on an oxidative transformation of the ring carbon–carbon double bond of the norbornene β-amino acids, followed by transformation of the resulted „all cis“ and „trans“ diformyl intermediates by fluorination with „chemodifferentiation“.