Efficient Syntheses of Some New Thiophene-Based Heterocycles

详细信息    查看全文

• 作者：Ahmed El-Mekabaty ; Osman M. O. Habib ; Evelin B. Moawad and Rehab M. Abo-Ouf
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：561-569
• 全文大小：723K
• ISSN：1943-5193

文摘

In this effort, 2-aminothiophene-3-carboxylate (1) was prepared using Gewald's methodology. This 2-aminothiophene derivative was diazotized and coupled with malononitrile to obtain the nitrile derivative (2), which was utilized as key synthon for the synthesis of polyfunctionally substituted heterocycles via its reactions with some nitrogen and carbon nucleophiles. On the other hand, a facile and convenient syntheses of thiazolidinone, pyrrolidinone, and chromene derivatives incorporating thiophene moiety via the versatile, readily accessible 2-aminothiophene-3-carboxylate (1) were also described.