meta-C−H Bromination on Purine Bases by Heterogeneous Ruthenium Catalysis
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- 作者：Svenja Warratz ; Dr. David J. Burns ; Cuiju Zhu ; Korkit Korvorapun ; Torben Rogge ; Julius Scholz ; Prof. Dr. Christian Jooss ; Prof. Dr. Dmitri Gelman and Prof. Dr. Lutz Ackermann
- 刊名：Angewandte Chemie
- 出版年：2017
- 出版时间：February 1, 2017
- 年：2017
- 卷：129
- 期：6
- 页码：1579-1582
- 全文大小：1507K
- ISSN：1521-3757
文摘
Methods for positionally selective remote C−H functionalizations are in high demand. Herein, we disclose the first heterogeneous ruthenium catalyst for meta-selective C−H functionalizations, which enabled remote halogenations with excellent site selectivity and ample scope. The versatile heterogeneous Ru@SiO2 catalyst was broadly applicable and could be easily recovered and reused, which set the stage for the direct fluorescent labeling of purines. In contrast to palladium, rhodium, iridium, or cobalt complexes, solely the ruthenium catalysis manifold provided access to meta-halogenated purine derivatives, illustrating the unique power of ruthenium C−H activation catalysis.