Nanovaccines: Multistaged Nanovaccines Based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy (Adv. Mater. 7/2017)
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- 作者：Flavia Fontana ; Mohammad-Ali Shahbazi ; Dongfei Liu ; Hongbo Zhang ; Ermei Mä ; kilä ; Jarno Salonen ; Jouni T. Hirvonen and Hé ; lder A. Santos
- 刊名：Advanced Materials
- 出版年：2017
- 出版时间：February 17, 2017
- 年：2017
- 卷：29
- 期：7
- 全文大小：2390K
- ISSN：1521-4095
文摘
In article 1603239, Flavia Fontana, Hélder A. Santos, and co-workers develop an innovative cancer nanovaccine by merging the adjuvant properties of the nanoparticles produced by nanoprecipitation in a microfluidic glass capillary device with high reproducibility, together with a biomimetic source of antigens derived from cancer-cell membranes. The nanovectors induce maturation of antigen-presenting cells and secretion of pro-inflammatory cytokines in vitro.