Targeted Cancer Therapy: pH-Switch Nanoprecipitation of Polymeric Nanoparticles for Multimodal Cancer Targeting and Intracellular Triggered Delivery of Doxorubicin (Adv. Healthcare Mater. 15/2016)
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- 作者：Bá ; rbara Herranz-Blanco ; Mohammad-Ali Shahbazi ; Alexandra R. Correia ; Vimalkumar Balasubramanian ; Tomá ; š Kohout ; Jouni Hirvonen and Hé ; lder A. Santos
- 刊名：Advanced Healthcare Materials
- 出版年：2016
- 出版时间：August 10, 2016
- 年：2016
- 卷：5
- 期：15
- 页码：1834
- 全文大小：2942K
- ISSN：2192-2659
文摘
Targeted theranostic nanoparticles with dual pH and magnetic responsive properties for intracellular delivery are described by B. Herranz-Blanco, H. A. Santos, and co-workers on page 1904. Using a pH-switch nanoprecipitation method in organic-free solvents, a polymeric-drug conjugate solid nanoparticle containing encapsulated superparamagnetic iron oxide nanoparticles and decorated with a tumor homing peptide, iRGD, are targeted to endothelial and metastatic cancer cells.