Nanofiltrated C1-esterase-inhibitor in the prophylactic treatment of bradykinin-mediated angioedema
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- 作者：Jens Greve ; Janina Hahn ; Melanie Nordmann ; Patrick J. Schuler ; Murat Bas ; Thomas K. Hoffmann ; Zuzana Hajdu ; Maria Buchberger and Ulrich Strassen
- 刊名：Transfusion
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：56
- 期：5
- 页码：1022-1029
- 全文大小：285K
- ISSN：1537-2995
文摘
Patients suffering from bradykinin-induced angioedema show recurrent swelling of subcutaneous and submucosal structures. Increased bradykinin levels lead to an increase in vascular permeability and edema formation. Current therapy consists of B2 bradykinin receptor antagonists, C1-esterase-inhibitor (C1-INH) concentrate, or the kallikrein inhibitor ecallantide. In most cases the treatment of acute attacks is sufficient. Prophylactic therapy is recommended only in severe cases. C1-INHc has been shown a safe and efficient option. Its effect on the quality of life has not yet been analyzed.