Utilization of G-Quadruplex-Forming Aptamers for the Construction of Luminescence Sensing Platforms
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- 作者：Dr. Dik-Lung Ma ; Wanhe Wang ; Zhifeng Mao ; Tian-Shu Kang ; Dr. Quan-Bin Han ; Dr. Philip Wai Hong Chan and Dr. Chung-Hang Leung
- 刊名：ChemPlusChem
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：82
- 期：1
- 页码：8-17
- 全文大小：1474K
- ISSN：2192-6506
文摘
Aptamers are nucleic acid sequences that can recognize and bind to analytes with high affinity and selectivity. Intriguingly, a number of aptamers undergo a conformational change within the G-quadruplex motif upon ligand binding. This Minireview aims to highlight interesting examples of luminescent G-quadruplex aptamer-based probes that have been developed in recent years. Various mechanisms and sensing modes are described, and the outlook and future directions of this field are also discussed.