Acute viral respiratory infections among children in MERS-endemic Riyadh, Saudi Arabia, 2012-2013

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• 作者：Shamsudeen F. Fagbo ; Musa A. Garbati ; Rami Hasan ; Dayel AlShahrani ; Mohamed Al-Shehri ; Tariq AlFawaz ; Ahmed Hakawi ; Tariq Ahmad Wani and Leila Skakni
• 刊名：Journal of Medical Virology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：89
• 期：2
• 页码：195-201
• 全文大小：831K
• ISSN：1096-9071

文摘

The emergence of the Middle East Respiratory Syndrome (MERS) in Saudi Arabia has intensified focus on Acute Respiratory Infections [ARIs]. This study sought to identify respiratory viruses (RVs) associated with ARIs in children presenting at a tertiary hospital. Children (aged ≤13) presenting with ARI between January 2012 and December 2013 tested for 15 RVs using the Seeplex^R RV15 kit were retrospectively included. Epidemiological data was retrieved from patient records. Of the 2235 children tested, 61.5% were ≤1 year with a male: female ratio of 3:2. Viruses were detected in 1364 (61.02%) children, 233 (10.4%) having dual infections: these viruses include respiratory syncytial virus (RSV) (24%), human rhinovirus (hRV) (19.7%), adenovirus (5.7%), influenza virus (5.3%), and parainfluenzavirus-3 (4.6%). Children, aged 9–11 months, were most infected (60.9%). Lower respiratory tract infections (55.4%) were significantly more than upper respiratory tract infection (45.3%) (P < 0.001). Seasonal variation of RV was directly and inversely proportional to relative humidity and temperature, respectively, for non MERS coronaviruses (NL63, 229E, and OC43). The study confirms community-acquired RV associated with ARI in children and suggests modulating roles for abiotic factors in RV epidemiology. However, community-based studies are needed to elucidate how these factors locally influence RV epidemiology. J. Med. Virol. 89:195–201, 2017.