Rh<sup>IIIsup>-Catalyzed CF<sub>3sub>-Carbenoid C-7 Functionalization of Indolines
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- 作者：Irina E. Iagafarova ; Daria V. Vorobyeva ; Dmitry A. Loginov ; Alexander S. Peregudov and Sergey N. Osipov
- 刊名：European Journal of Organic Chemistry
- 出版年：2017
- 出版时间：January 26, 2017
- 年：2017
- 卷：2017
- 期：4
- 页码：840-845
- 全文大小：756K
- ISSN：1099-0690
文摘
An efficient method for the CF<sub>3sub>-carbenoid C-7 functionalization of N-pyrimidylindolines has been developed. This protocol uses readily available methyl 3,3,3-trifluoro-2-diazopropionate as a cross-coupling partner and smoothly proceeds under chelation-controlled Rh<sup>IIIsup> catalysis. The reactions provide the indoline products with high regioselectivity within a few hours and allow for the introduction of both the CF<sub>3sub> and carboxylate functions at the C-7 position.