文摘
Four new ent-pimarane diterpenes were isolated from the EtOH extract of Aralia dumetorum, together with three known compounds involving ent-pimar-8(14),15-dien-19-oic acid (5), ent-pimar-8(14),15-dien-19-ol (6), and ent-kaur-16-en-19-oic acid (7). By detailed analyses of the MS, IR, and NMR data, the structures of four new diterpenes were characterized as (5β,9β,10,13)-pimara-6,8(14),15-trien-18-oic acid (1), (5β,7β,9β,10,13)-7-methoxypimara-8(14),15-dien-18-oic acid (2), (5β,9β,10,13,14β)-14-methoxypimara-7,15-dien-18-oic acid (3), and (5β,10,13,14)-14-hydroxypimara-7,9(11),15-trien-18-oic acid (4). The cytotoxic activities of compounds 1 – 7 were assayed in vitro through MTT method.