A Cascade C-H-Functionalization/Cyclization Reaction of Indoles with α-Halo or α-Sulfonyloxy Ketones for the Synthesis of Dihydropyrimidoindolone Derivatives

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• 作者：Zi-Jun Wu ; Ya-Qiong Li and Zhi-Zhen Huang
• 刊名：European Journal of Organic Chemistry
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：2016
• 期：32
• 页码：5399-5404
• 全文大小：924K
• ISSN：1099-0690

文摘

A new cascade C–H-functionalization/cyclization reaction of N-carbamoylindoles 1 with α-halo, α-mesyloxy, or α-tosyloxy ketones 2 has been developed under rhodium(III) catalysis, leading to dihydropyrimido[1,6-a]indolone derivatives 3 in moderate to excellent yields.