ChemInform Abstract: Synthesis of Fluorinated 1,4,5-Substituted 1,2,3-Triazoles by RuAAC Reaction.

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• 作者：Qian Shen ; En-jian Han ; Yan-gen Huang ; Qing-Yun Chen and Yong Guo
• 关键词：triazole derivatives ; ring closure reactions ; annulation reactions ; cycloaddition reactions ; regioselective reactions
• 刊名：ChemInform
• 出版年：2016
• 出版时间：April, 2016
• 年：2016
• 卷：47
• 期：18
• 全文大小：32K
• ISSN：1522-2667

文摘

A wide range of trisubstituted 1,2,3-triazoles bearing fluorinated groups, -CH₂-CF₃ or -S-CF₃, at C-5 and aryl groups at C-4 of the triazole ring is regioselectively obtained by convenient azide-alkyne Huisgen 1,3-dipolar cycloaddition reaction of internal alkynes catalyzed by a ruthenium complex.