Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers
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- 作者：Bart A. W. Jacobs ; Maarten J. Deenen ; Dick Pluim ; J. G. Coen van Hasselt ; Martin D. Krhenbü ; hl ; Robin M. J. M. van Geel ; Niels de Vries ; Hilde Rosing ; Didier Meulendijks ; Artur M. Burylo ; Annemieke Cats ; Jos H. Beijnen ; Alwin D. R. Huitema and Jan H. M. Schellens
- 刊名：British Journal of Clinical Pharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：82
- 期：3
- 页码：706-716
- 全文大小：903K
- ISSN：1365-2125
文摘
The enzymatic activity of dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) are important for the tolerability and efficacy of the fluoropyrimidine drugs. In the present study, we explored between-subject variability (BSV) and circadian rhythmicity in DPD and TS activity in human volunteers.