Cover Picture: Identification of N-Arylated NH125 Analogues as Rapid Eradicating Agents against MRSA Persister Cells and Potent Biofilm Killers of Gram-Positive Pathogens (ChemBioChem 4/2017)

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• 作者：Yasmeen Abouelhassan ; Akash Basak ; Hussain Yousaf and Prof. Robert W. Huigens III
• 刊名：ChemBioChem
• 出版年：2017
• 出版时间：February 16, 2017
• 年：2017
• 卷：18
• 期：4
• 页码：336
• 全文大小：699K
• ISSN：1439-7633

文摘

The cover picture shows the destruction of a bacterial membrane by a new NH125 analogue. Through chemical synthesis and biological evaluation, the authors have identified potent N-arylated compounds that rapidly kill MRSA persister cells (99.99 % in 30 minutes) and eradicate surface-attached bacterial biofilms of multiple Gram-positive pathogens through the destructive lysis of bacterial membranes. These N-arylated NH125 analogues demonstrated enhanced activity in killing persister cells and eradicating biofilm when tested alongside a structurally diverse panel of membrane-active agents. More information can be found in the communication by R. W. Huigens III et al. on page 352 in Issue 4, 2017 (DOI: ref="https://doi.org/10.1002/cbic.201600622" rel="references:https://doi.org/10.1002/cbic.201600622">10.1002/cbic.201600622).