Programmable DNA Hydrogels Assembled from Multidomain DNA Strands

详细信息    查看全文

• 作者：Dr. Huiling Jiang ; Victor Pan ; Skanda Vivek ; Prof. Eric R. Weeks and Prof. Yonggang Ke
• 刊名：ChemBioChem
• 出版年：2016
• 出版时间：June 16, 2016
• 年：2016
• 卷：17
• 期：12
• 页码：1156-1162
• 全文大小：1838K
• ISSN：1439-7633

文摘

Hydrogels are important in biological and medical applications, such as drug delivery and tissue engineering. DNA hydrogels have attracted significant attention due to the programmability and biocompatibility of the material. We developed a series of low-cost one-strand DNA hydrogels self-assembled from single-stranded DNA monomers containing multiple palindromic domains. This new hydrogel design is simple and programmable. Thermal stability, mechanical properties, and loading capacity of these one-strand DNA hydrogels can be readily regulated by simply adjusting the DNA domains.