Atypical teratoid/rhabdoid tumor arising in a malignant glioma

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• 作者：Barbara Bozzai ; Martin Hasselblatt ; Eszter Turá ; nyi ; Michael C. Frü ; hwald ; Reiner Siebert ; Susanne Bens ; Reinhard Schneppenheim ; Marcel Kool ; Gá ; bor Stelczer ; Tibor Hortobá ; gyi and Peter Hauser
• 刊名：Pediatric Blood & Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：64
• 期：1
• 页码：96-99
• 全文大小：551K
• ISSN：1545-5017

文摘

Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.