Splenic infarction associated with acute infectious mononucleosis due to Epstein-Barr virus infection

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• 作者：Dae-Hyuk Heo ; Dae-Youb Baek ; Sang-Min Oh ; Joo-Hee Hwang ; Chang-Seop Lee and Jeong-Hwan Hwang
• 刊名：Journal of Medical Virology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：89
• 期：2
• 页码：332-336
• 全文大小：180K
• ISSN：1096-9071

文摘

The purpose of this study was to report a case of a previously healthy 20-year-old woman diagnosed with splenic infarction following infectious mononucleosis (IM) by Epstein–Barr virus (EBV) infection and to perform the first systematic review of the clinical characteristics of splenic infarction associated with IM. A systematic review was conducted using English, French, and Japanese literatures of splenic infarction associated with IM due to EBV infection published between 1961 and 2015 in PubMed Medline. A total of 19 cases were extracted from the collected articles. Left upper quadrant (LUQ) pain was observed in 15 (79%) patients. Splenectomy was performed in five (26%) cases, among which four patients presented with stable vital signs. Splenic rupture was accompanied in two (10%) patients. The median time from the onset of IM symptoms to the diagnosis of splenic infarction was 5 days (range, 1–25 days). Fourteen (74%) of 19 patients experienced improvement through medical treatment, and there were no deaths. Splenic infarction associated with IM due to EBV infection can show a favorable clinical outcome after medical treatment. Clinicians should consider the possibility of splenic infarction when patients with IM experience LUQ pain. J. Med. Virol. 89:332–336, 2017.