Identification of Endocrine Disrupting Chemicals using a Virus-Based Colorimetric Sensor

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• 作者：Dr. Jong-Sik Moon ; Yujin Lee ; Dr. Dong-Myeong Shin ; Chuntae Kim ; Won-Geun Kim ; Minji Park ; Jiye Han ; Hyerin Song ; Prof. Kyujung Kim and Prof. Jin-Woo Oh
• 刊名：Chemistry – An Asian Journal
• 出版年：2016
• 出版时间：November 7, 2016
• 年：2016
• 卷：11
• 期：21
• 页码：3097-3101
• 全文大小：1290K
• ISSN：1861-471X

文摘

A simple and portable colorimetric sensor based on M13 bacteriophage (phage) was devised to identify a class of endocrine disrupting chemicals, including benzene, phthalate, and chlorobenzene derivatives. Arrays of structurally and genetically modified M13 bacteriophage were fabricated so as to produce a biomimetic colorimetric sensor, and color changes in the phage arrays in response to several benzene derivatives were characterized. The sensor was also used to classify phthalate and chlorobenzene derivatives as representatives of endocrine disrupting chemicals. The characteristic color patterns obtained on exposure to various benzene derivatives enabled similar chemical structures in the vapor phase to be classified. Our sensing approach based on the use of a genetically surface modified M13 bacteriophage offers a promising platform for portable, simple environmental monitors that could be extended for use in numerous application areas, including food monitoring, security monitoring, explosive risk assessment, and point of care testing.