Accelerated skin wound healing using electrospun nanofibrous mats blended with mussel adhesive protein and polycaprolactone

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• 作者：Bum Jin Kim ; Hogyun Cheong ; Eun-Som Choi ; So-Hee Yun ; Bong-Hyuk Choi ; Ki-Soo Park ; Ick Soo Kim ; Dae-Hwan Park and Hyung Joon Cha
• 刊名：Journal of Biomedical Materials Research Part A
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：105
• 期：1
• 页码：218-225
• 全文大小：519K
• ISSN：1552-4965

文摘

Nanofibrous scaffolds have been assessed as one of many promising tissue engineering scaffolds to be utilized for wound-healing applications. Previously, we reported multi-functionalized electrospun nanofibrous scaffolds blended with mussel adhesive protein (MAP) and polycaprolactone (PCL), which provide durable mechanical strength, cell-friendly environments, and a substantial ability to capture diverse bioactive molecules without any surface modifications. In the present work, we applied the blended nanofibrous mats of MAP and PCL for in vivo skin wound healing. The nanofibrous mats showed accelerated regeneration in a rat skin wound-healing model, which might be attributed to a highly compatible environment for keratinocyte cell growth, an ability to capture inherent growth factors, and an efficient exudate absorption capacity. Thus, this work would suggest that adhesive property of scaffold could be a factor of successful application for wound healing. The MAP-blended nanofibers could also be potentially exploited for diverse tissue regeneration applications.