Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay

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• 作者：Ying-Shan Han ; Narsimha Reddy Penthala ; Maureen Oliveira ; Thibault Mesplè ; de ; Hongtao Xu ; Yudong Quan ; Peter A. Crooks and Mark A. Wainberg
• 刊名：Journal of Medical Virology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：89
• 期：3
• 页码：397-407
• 全文大小：465K
• ISSN：1096-9071

文摘

Dengue virus (DENV) causes a variety of difficult-to-treat diseases that threaten almost half of the world's population. Currently, no effective vaccine or antiviral therapy is available. We have examined a series of synthetic resveratrol analogs to identify potential anti-DENV agents. Here, we demonstrate that two resveratrol analogs, PNR-4-44 and PNR-5-02, possess potent anti-DENV activity with EC₅₀ values in the low nanomolar range. These two resveratrol analogs were shown to mainly target viral RNA translation and viral replication, but PNR-5-02 is also likely to target cellular factors inside host cells. Although the precise molecular mechanism(s) mediating anti-DENV activities have not been elucidated, further structure-guided design might lead to the development of newer improved resveratrol derivatives that might have therapeutic value. J. Med. Virol. 89:397–407, 2017.