Detection of human papillomavirus infection in oral squamous cell carcinoma: a cohort study of Japanese patients

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• 作者：Atsumu Kouketsu ; Ikuro Sato ; Satoko Abe ; Mariko Oikawa ; Yoshinaka Shimizu ; Tetsu Takahashi and Hiroyuki Kumamoto
• 刊名：Journal of Oral Pathology & Medicine
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：45
• 期：8
• 页码：565-572
• 全文大小：824K
• ISSN：1600-0714

文摘

Recent evidence suggests that human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is a separate HNSCC subgroup with distinct epidemiology, histopathological characteristics, therapeutic response to chemotherapy and radiation, and clinical outcome. This study aimed to investigate the role of HPV infection in oral squamous cell carcinoma (OSCC) and the correlation between HPV infection, tumor suppressor protein p16 expression, and clinicopathological features in Japanese patients.