Oxidative stress controlling agents are effective for small intestinal injuries induced by non-steroidal anti-inflammatory drugs
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- 作者：Yoshiyasu Kono ; Seiji Kawano ; Akinobu Takaki ; Yasuyuki Shimomura ; Masahiro Onji ; Hisashi Ishikawa ; Sakuma Takahashi ; Joichiro Horii ; Sayo Kobayashi ; Daisuke Kawai ; Kazuhide Yamamoto and Hiroyuki Okada
- 刊名：Journal of Gastroenterology and Hepatology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：32
- 期：1
- 页码：136-145
- 全文大小：780K
- ISSN：1440-1746
文摘
Video-capsule endoscopy (VCE) has shown that intestinal ulcers are common in non-steroidal anti-inflammatory drugs (NSAIDs) users, although the mechanisms and management have not been clearly defined. To explore the contribution of oxidative stress and potential of anti-oxidants for NSAIDs-induced intestinal ulcers, we assessed human serum oxidative stress balance and the effect of anti-oxidants using a mouse model.